The Dr. Gabrielle Lyon Show

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The Dr. Gabrielle Lyon Show, a podcast hosted by Dr. Gabrielle Lyon.
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Member Since: July 10, 2023

Latest Episodes

GLP-1 & PCOS Breakthroughs: How Ozempic is Changing Women’s Health | Dr. Melanie Cree

GLP-1 & PCOS Breakthroughs: How Ozempic is Changing Women’s Health | Dr. Melanie Cree

In this episode, I’m joined by Dr. Melanie Cree—physician-scientist, pediatric endocrinologist, and one of the leading researchers redefining how we understand and treat Polycystic Ovary Syndrome (PCOS). PCOS affects millions of women, yet it's still underdiagnosed, misunderstood, and often mistreated. Dr. Cree cuts through the confusion, offering a deeply scientific yet compassionate look at what’s really driving this complex condition—from insulin resistance and mitochondrial dysfunction to skeletal muscle quality and fertility trajectories across a woman’s lifespan.

We cover:

  • Why PCOS isn’t a single disease—and what two phenotypes may explain the full picture
  • How muscle, liver, and fat interact in PCOS
  • The misunderstood role of testosterone, insulin, and SHBG in diagnosis
  • What muscle biopsies reveal about teenage girls with PCOS
  • Intramuscular fat, mitochondrial impairment, and the true cost of sedentary muscle
  • How early lifestyle and exercise interventions could change the future of PCOS care
  • What GLP-1 agonists and amino acid supplements might offer for treatment

Whether you’re a clinician, patient, or advocate for women’s health, this episode will give you a whole new lens on PCOS—and why skeletal muscle may be the most overlooked (and powerful) organ in the conversation.

Who is Dr. Melanie Cree?

Dr. Melanie Cree is a board-certified pediatric endocrinologist and Associate Professor at the University of Colorado and Children’s Hospital Colorado, where she directs a leading multidisciplinary PCOS clinic. Her research bridges metabolic medicine and muscle physiology, with clinical trials exploring semaglutide, amino acid therapy, liver metabolism, and insulin resistance in adolescents.

Forever Strong Summit 2025:

The Forever Strong Summit is a live event on April 27, 2025 in Houston, TX, designed to help you build strength, resilience, and longevity from the inside out. Featuring top minds in medicine, military, and mindset, you’ll walk away with practical tools to upgrade your health, sharpen your focus, and take ownership of your life. Whether you're a clinician, athlete, or simply ready to step into your next level—this is where science meets action. Get your ticket now! https://drgabriellelyon.com/forever-strong-summit-2025/

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The Science of Joint Health: How to Keep Your Bones Strong for Life | Dr. Jocelyn Wittstein

The Science of Joint Health: How to Keep Your Bones Strong for Life | Dr. Jocelyn Wittstein

In this episode, I’m joined by Dr. Jocelyn Wittstein—orthopedic surgeon, sports medicine expert, and Associate Professor at Duke University—for a powerful and practical conversation about  bone and joint health across the lifespan. From the challenges of frozen shoulder and arthritis to the truth about running and menopause hormone therapy, this episode is your definitive guide to staying strong, mobile, and pain-free well into your 40s, 50s, and beyond.

We cover:

  • Why your joints and bones start changing after 30—and what to do about it
  • The difference between male and female aging (and why 50 hits women harder)
  • The role of estrogen in health, inflammation, muscle mass, and osteoporosis
  • The truth about running and arthritis: myth vs. reality
  • How to actually build stronger bones: plyometrics, impact, and intensity
  • Why frozen shoulder happens and how to treat it early
  • The supplements Dr. Wittstein actually recommends (and which ones she used to dismiss)
  • What we’re learning about GLP-1 medications and their surprising effect on bone and joint health

Whether you’re an athlete, a parent, or entering perimenopause, this conversation is a masterclass in movement longevity and joint and bone preservation.

Who is Dr. Jocelyn Wittstein?

Dr. Jocelyn Wittstein is an Associate Professor of Orthopedic Surgery at Duke University specializing in sports medicine and women's joint health. As a leading researcher and clinician, she’s pioneered work on arthritis, adhesive capsulitis, and the role of hormones in bone and joint aging. She is also co-author of the upcoming book The Complete Bone and Joint Health Plan (May 2025), a practical guide for women who want to move well and stay strong at every stage of life.

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Resilient by Design: A Navy SEAL-Turned-Doctor’s Roadmap to Success | Shane Kronstedt MD

Resilient by Design: A Navy SEAL-Turned-Doctor’s Roadmap to Success | Shane Kronstedt MD

In this episode, I’m joined by Dr. Shane Kronstedt—former Navy SEAL, physician, surgical resident, and most importantly, my husband—for a powerful conversation about discipline, resilience, and the real-life moments that define us. From his early years of martial arts and mixed martial arts to surviving Hell Week and life-or-death missions in Afghanistan and Uganda, Shane shares how pressure creates clarity, why mindset matters most, and what it truly means to lead by example. This deeply personal episode gives you a rare glimpse into the man behind the mission.

We cover:

  • Why Shane chose the most dangerous path on purpose—and what it taught him
  • What Hell Week is really like (and why most fail)
  • His perspective on “one moment of weakness for a lifetime of regret”
  • Lessons learned from combat trauma and performing surgery in war zones
  • The truth about motivation, mental toughness, and doing things that suck
  • Why preparation beats panic and mindset > emotion
  • The relationship between high performers, adversity, and identity
  • What it’s like building a family, business, and legacy

Whether you’re a parent, athlete, medical professional, or someone who wants to be better under pressure, this episode will challenge you to redefine your limits and commit to something greater than yourself.

Please be advised: This episode contains some strong language and may not be suitable for all audiences.

Who is Shane Kronstedt?

Dr. Shane Kronstedt Shane was a Navy SEAL and combat medic with ten years of active duty service. His time overseas treating patients inspired him to become a surgeon. He deployed to Afghanistan, Europe, the Horn of Africa, and South America. Some of his awards include the Navy Commendation Medal, the Army Commendation Medal, The Joint Services Achievement Medal, and Navy Achievement Medal x2. He graduated from Rutgers Robert Wood Johnson Medical School with AOA Honors in 2023 and is currently a resident in urologic surgery at Baylor College of Medicine.

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Comfort is Destroying Your Health: Why Stress is Not the Enemy | Jeff Krasno

Comfort is Destroying Your Health: Why Stress is Not the Enemy | Jeff Krasno

Jeff Krasno’s personal health transformation—reversing diabetes, shedding 60 pounds, and reclaiming his health at age 50—is a masterclass in what he calls “good stress.” In this episode, we dive into the simple but powerful idea that discomfort might just be the medicine we all need. Jeff, the founder of Commune and host of the Commune podcast, shares how fasting, cold exposure, resistance training, and attention to modern habits helped him regain his energy, build muscle, and thrive.

Together, we discuss how metabolic dysfunction has become the norm, how adaptive stress responses can be harnessed to reverse chronic illness, and why building muscle is not only the antidote to obesity but also a critical factor in longevity. If you’re interested in reclaiming your vitality and learning how to work with—not against—your biology, this episode will speak to you.

We cover:

  • Jeff’s story of personal health transformation at midlife
  • What “good stress” is and how to harness it to improve health
  • Why chronic ease leads to chronic disease
  • Cold therapy, fasting, and training as adaptive stressors
  • The importance of resistance training for blood sugar control
  • How metabolic dysfunction hides in plain sight
  • Practical tips to increase non-exercise activity thermogenesis (NEAT)
  • Building muscle as the path to longevity and disease prevention

Who is Jeff Krasno?

Jeff Krasno is the co-founder and CEO of Commune, a masterclass platform for personal and societal well-being. He hosts the Commune podcast, where he’s interviewed luminaries like Deepak Chopra, Gabor Maté, and Matthew McConaughey. Jeff also writes a weekly personal essay called “Commusings,” delivered to over a million subscribers every Sunday. His new project, Good Stress, is an online course, upcoming book, and developing TV series, built on the wellness strategies that helped him reclaim his health after a diabetes diagnosis. He is also the co-creator of the global wellness event series Wanderlust and was selected for Oprah’s SuperSoul100 in 2016.

This episode is brought to you by:


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Steroids & Testosterone: The Science Behind Anabolic Therapies | Nelson Vergel

Steroids & Testosterone: The Science Behind Anabolic Therapies | Nelson Vergel

Nelson Vergel’s story is one of resilience, perseverance, and an unrelenting drive to defy the odds. In the mid-1980s, he was handed what many would have considered a death sentence—an HIV diagnosis at a time when there were no effective treatments, no clear answers, and little hope. Today, he is a beacon of knowledge and empowerment for those seeking to take control of their health, whether they are dealing with wasting conditions, hormone deficiencies, or simply aiming for peak performance. Nelson has spent decades researching and advocating for hormone health, muscle preservation, and medical autonomy, particularly for those facing wasting conditions like HIV and cancer. His work has helped shape the conversation around androgen therapies, the role of anabolic agents in aging, and the intersection of GLP-1 medications with muscle loss.

We cover:

  • Nelson's personal journey from an HIV diagnosis to hormone optimization
  • The history, misconceptions and stigma surrounding anabolic agents
  • The differences between various anabolic agents and how they work
  • The impact of GLP-1 medications on lean mass and how to mitigate muscle loss
  • Best practices for hormone monitoring and optimization

If you want to hear an inspiring story of overcoming the odds to take control of your own health or you’re curious about anabolic therapies and longevity, you can’t miss this one.   

Who is Nelson Vergel?

Nelson Vergel is a chemical engineer, author, and health advocate who has made significant contributions to men's health and hormone optimization. His most recent book, Beyond Testosterone, provides a detailed color guide to educate clinicians and patients about the latest advances in the use of testosterone, anabolics, and other therapies to maximize health and productivity.

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The Truth About Calories and Weight Loss | Dr. James Hill

The Truth About Calories and Weight Loss | Dr. James Hill

Dr. James Hill—a expert on obesity, metabolism, and long-term weight management—joins me this week to unpack the biggest challenges in sustainable fat loss. Dr. Hill has spent decades researching weight control and the factors that determine whether people can keep weight off long-term. We discuss the science behind energy balance, metabolic flexibility, and why long-term weight loss is about more than just diet and exercise. He shares insights from his groundbreaking work with the National Weight Control Registry, the role of GLP-1 medications, and why physical activity is the key to preventing weight regain.

We cover:

  • The critical differences between weight loss and weight maintenance
  • Why physical activity is perhaps more important for keeping weight off than losing it
  • The National Weight Control Registry: lessons from long-term weight loss success stories
  • How metabolism, muscle mass, and energy expenditure affect weight regain
  • The role of protein and resistance training in preserving lean mass
  • The impact of GLP-1 medications on weight loss and why most people regain weight after stopping them
  • The psychology of weight maintenance: mindset, self-monitoring, and behavior change

If you’ve ever struggled to keep weight off, or you’re interested in the latest research on metabolic health and sustainable weight management, this episode is a must-listen.

Who is Dr. James Hill?

Dr. James Hill is an internationally recognized expert on obesity, metabolism, and weight management. He is the co-founder of the National Weight Control Registry, the largest ongoing study tracking individuals who have successfully lost weight and kept it off long-term. Dr. Hill has published over 400 scientific articles and has led pioneering research on energy balance, metabolic flexibility, and the role of physical activity in weight maintenance. He is a professor at the University of Alabama at Birmingham and has served as the President of The Obesity Society. His work has been instrumental in shaping modern obesity treatment and prevention strategies.

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The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD

The Science of Optimizing Your Testosterone | Abraham Morgentaler, MD

In this episode, Dr. Abraham Morgentaler—an expert in urology and hormone health—helps unpack the biggest myths and misconceptions surrounding testosterone therapy for both men and women. He shares his pioneering research on testosterone replacement therapy, challenging outdated fears about its link to prostate cancer and highlighting the latest findings on how hormone therapy can impact overall health, libido, and longevity. The conversation explores the controversial history of testosterone in medicine, the common mismanagement of hormone deficiencies, and why free testosterone may be one of the most important markers for health.

We cover:

  • The truth behind the testosterone-prostate cancer debate
  • How testosterone deficiency is linked to obesity, cardiovascular disease, and dementia
  • The stigma around testosterone therapy and why so many people remain untreated
  • The effects of testosterone therapy on fertility, muscle mass, and mental well-being
  • The role of testosterone in women's health and aging
  • The latest advancements in testosterone treatments and how they compare

Whether you’re considering testosterone therapy, navigating hormone-related issues, or just interested in optimizing your health, this episode offers critical insights that could reshape your understanding of testosterone and its role in overall well-being.

Who is Abraham Morgentaler?

Dr. Abraham Morgentaler is a leading expert in men’s health and a pioneer in the treatment of testosterone deficiency. His research helped overturn the long-held belief that testosterone therapy increases prostate cancer risk, and he has published over 200 scientific articles on testosterone, prostate cancer, and male sexual health. A Harvard-trained urologist, he is currently the Blavatnik Faculty Fellow in Health and Longevity at Harvard Medical School. Dr. Morgentaler is also the founder of Men’s Health Boston and co-founder of the Androgen Society, and he continues to educate clinicians worldwide through his virtual fellowship and best-selling books on men's health.

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The Truth About Nutrition: How You Can Take a Science-Based Approach | Bradley Johnston PhD

The Truth About Nutrition: How You Can Take a Science-Based Approach | Bradley Johnston PhD

Misinformation in nutrition is rampant. From demonizing red meat to hyping plant-based diets, conflicting advice has left many people confused about what’s truly evidence-based. In this episode, I am joined by Dr. Bradley Johnston, an expert in evidence-based nutrition and public health policies, to separate fact from fiction. With nearly 200 peer-reviewed publications, Dr. Johnston has challenged conventional wisdom—including recommendations from major organizations like the World Health Organization. He shares how evidence-based practices should guide our dietary choices, the importance of systematic reviews and meta-analyses, and how cognitive biases influence the research we trust.

Key Points:

  • How evidence-based guidelines are formed—and why they sometimes change
  • The three pillars of evidence-based practice and why patient values matter
  • Why most nutrition studies aren’t as strong as we think—and how to critically evaluate them
  • What the best available research actually says about dietary patterns for longevity
  • The role of AI in research and whether it’s a help or hindrance to scientific rigor

If you’ve ever questioned dietary guidelines, nutrition headlines, or conflicting health advice, this episode is a must-listen. Get ready to rethink everything you thought you knew about nutrition.

Who is Dr. Bradley Johnston?

Dr. Bradley Johnston is an Associate Professor at Texas A&M University, specializing in evidence-based nutrition, and the methodology of patient-reported outcomes, randomized clinical trials, systematic reviews, and clinical and public health practice guidelines.

With a PhD in experimental medicine from the University of Alberta and post-doctoral training in evidence-based practice, epidemiology and biostatistics from Oxford and McMaster University, his research focuses on advancing human health research methodology to improve clinical and dietary practice recommendations and public health policies. He co-leads EvidenceBasedNutrition.org and NutriRECS, develops nutrition education resources (e.g. Nutrition Users’ Guides), and currently serves as Co-Chair of the Canadian Pediatric Obesity Management Guidelines, ensuring clinical and public health guidelines are backed and transparently supported by the best available evidence, including end user values and preferences, absolute estimates of effect and the certainty of evidence for estimates of effect. His overall aim is to empower patients, clients and members of the public to make fully-informed health care decisions based on the central tenets of evidence-based practice and policy.

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Plastic Surgery Myth Busting: The Truth About Breast Implants, Botox, and Beauty Trends | Dr. Kristy Hamilton

Plastic Surgery Myth Busting: The Truth About Breast Implants, Botox, and Beauty Trends | Dr. Kristy Hamilton

In this episode, I sit down with Dr. Kristy Hamilton, a board-certified plastic surgeon, to explore the latest advancements in aesthetic medicine, the impact of social media on beauty standards, and the reality of breast implant illness. Dr. Hamilton shares her expert insights on facial rejuvenation, fat transfer, the safety of fillers, and new biostimulators while debunking common myths around plastic surgery. We also dive deep into the controversial rise of explant surgeries, the latest data on BII, and how surgical and non-surgical options can help individuals feel more confident in their skin. From the influence of celebrity procedures to the evolution of breast implants, this conversation is packed with science-backed insights, expert advice, and practical takeaways for those considering aesthetic procedures.

Key Points:

  • The truth behind plastic surgery and celebrity transformations
  • What can and can’t be fixed through diet, exercise, and non-surgical treatments
  • Breast Implant Illness: What the latest research reveals
  • The risks of capsulectomy and explant regret
  • The role of fillers, biostimulators, and fat transfer in facial rejuvenation
  • How to approach facelifts and natural aesthetic treatments
  • Best skincare practices for long-term anti-aging

Who is Dr. Kristy Hamilton?

Kristy Hamilton, MD, FACS is a plastic and reconstructive surgeon in Houston, Texas who specializes in aesthetic surgery of the face, breast, and body. An artist and a scientist, Dr. Hamilton blends form and function with an artistic eye to achieve beautiful, natural results. She understands patients’ individual needs and applies her surgical skill with meticulous detail, customized to each patient’s anatomy. Her patients’ well-being is her utmost concern, and she is well known for her compassionate care.

Dr. Hamilton offers the full range of bespoke aesthetic plastic surgery including rhinoplasty, eyelid surgery, facelifts and facial rejuvenation, necklifts, fat transfer, chin surgery, breast augmentation and lifts, body contouring and liposuction, as well as reconstructive facial and breast surgery.

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Bio of The Dr. Gabrielle Lyon Show

The Dr. Gabrielle Lyon Show, a podcast hosted by Dr. Gabrielle Lyon. This show is dedicated to promoting a healthy world through transparent conversations. With a focus on education, understanding, strength, and health, Dr. Lyon aims to empower listeners to take control of their own well-being.

The Dr. Gabrielle Lyon Show provides a framework for navigating the vast health and wellness space. The goal is to equip listeners with the knowledge and tools to become the champions of their own lives. Through engaging discussions with highly trustworthy professionals, the show explores both the art and science of wellness, covering aspects that are physical and mental in nature.

Dr. Gabrielle Lyon herself is a physician with specialized training from Washington University. She is passionate about serving innovators, mavericks, and leaders in their respective fields, as well as working closely with the Special Operations Military. Dr. Lyon is the founder of the Institute of Muscle-Centric Medicine®, and her expertise in muscle-centric health and overall wellness has earned her recognition and a global patient base.

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