The Dr. Gabrielle Lyon Show

Heart disease is the leading cause of death for women—yet it's still treated like a man’s disease. In this powerful conversation, Dr. Martha Gulati, a cardiologist and pioneer in women’s cardiovascular health, exposes the systemic gaps that leave women underdiagnosed, undertreated, and often unheard. Together, we unpack the critical differences in how heart disease presents in women, why standard diagnostic tools fall short, and what every woman needs to know about risk factors like pregnancy complications, hormone therapy, statin use, and even environmental exposures. Dr. Gulati also reveals the truth behind hormone therapy myths, explains how soft plaque really forms, and why fitness should be considered frontline prevention.

You’ll learn:

• Why women’s heart symptoms are often mistaken for anxiety
• What tests to ask for to asses your risk of heart disease
• How statins, hormone therapy, and fitness interact with risk
• What the new “Prevent" risk score includes—and why it matters
• Why women get more benefits from exercise than men
• How pollution, stress, and pregnancy complications shape long-term risk

Whether you’re in your 20s or postmenopausal, this episode will empower you to take charge of your heart health, ask better questions, and get the care you deserve.

Who is Dr. Martha Gulati?

Dr. Martha Gulati is a professor of cardiology at the Smidt Heart Institute at Cedars-Sinai, where she serves as Director of Prevention and Associate Director of the Barbra Streisand Women’s Heart Center. She is the immediate past president of the American Society for Preventive Cardiology and previously served as the inaugural Chief of Cardiology at the University of Arizona. A leading voice in women’s heart health, Dr. Gulati chaired the first national chest pain guidelines and is the author of the best-selling book Saving Women’s Hearts.

This episode is brought to you by:

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Find Dr. Martha Gulati At:

• Website - https://drmarthagulati.com/
• LinkedIn - https://www.linkedin.com/in/martha-gulati-9b410496/
• Instagram - https://www.instagram.com/drmarthagulati/
• X/Twitter - https://x.com/drmarthagulati
• Cedars-Sinai - https://www.cedars-sinai.org/provider/martha-gulati-2036029.html
• Her book Saving Women's Hearts: https://www.amazon.ca/Saving-Womens-Hearts-Conventional-Strategies/dp/0470678453

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Muscle health isn’t just about how much protein you eat—it’s about how your body uses it. And for people with obesity or advancing age, that process can become less effective, even with optimal nutrition.

In this episode, I am joined by Dr. Nick Burd, one of the world’s leading researchers in muscle metabolism, to unpack the concept of anabolic resistance—when muscle doesn’t respond normally to protein and/or exercise. Together, we explore how aging, obesity and even the way foods are combined on your plate can impact muscle remodeling, recovery, and growth. Dr. Burd also shares why plant-based proteins often fall short, why protein efficiency matters more than quantity, and how endurance and resistance training affect nutrient use differently.

You’ll learn:

• What anabolic resistance is—and why it matters
• How to improve protein efficiency and muscle quality over time
• Why food matrix, and timing can change your results
• Key differences in nutrition strategies for endurance vs. strength athletes

Whether you're focused on longevity, performance, or helping someone break through a plateau, this episode delivers the research-backed information you’ve been looking for.

Who is Dr. Nick Burd?

Dr. Nick A. Burd is a muscle-metabolism scientist and professor at the University of Illinois at Urbana-Champaign, where he leads the Nutrition & Exercise Performance Research Group. Originally from the Midwest, he trained under renowned experts around the world before focusing his research on how protein and exercise influence muscle health across the lifespan. His work uses advanced tracer methods and muscle biopsies to explore optimal protein intake, plant vs. animal protein quality, and strategies to combat anabolic resistance.

This episode is brought to you by:

• LMNT - Get your free LMNT Sample Pack → https://drinklmnt.com/DRLYON
• Cozy Earth - Use code DRLYON for up to 40% off - https://cozyearth.com
• Timeline - Get 20% off your order of Mitopure - https://timeline.com/LYON
• OneSkin - Get 15% off with code DRLYON → https://oneskin.co

Find Dr. Nick Burd At:

• University of Illinois at Urbana-Champaign: https://ahs.illinois.edu/burd
• X (Twitter): https://x.com/Nicholas_Burd
• Google Scholar: https://scholar.google.com/citations?user=BMvk_GMAAAAJ&hl=en
• LinkedIn: https://www.linkedin.com/in/nicholas-burd-5972b783/

Find Me At:

• Instagram:@drgabriellelyon  
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• Facebook: facebook.com/doctorgabriellelyon
• YouTube: youtube.com/@DrGabrielleLyon
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Did you know every 40 seconds someone in the U.S. has a heart attack—and 1 in 5 never even see it coming? This week, I am joined by preventive cardiologist Dr. Michael Twyman as we discuss cutting-edge diagnostics, the endothelial glycocalyx, nitric oxide biology, and why muscle mass is your heart’s best friend. Learn the practical steps and questions to ask to protect your heart before symptoms appear.

Together, we explore:

• Why silent heart attacks are so prevalent
• The role of nitric oxide and the endothelial glycocalyx in vascular health
• The critical link between muscle mass, VO₂ max, and heart resilience
• How advanced imaging and testing are changing prevention
• Debunking common myths around cardiovascular risk
• Supplements and diagnostics Dr. Twyman uses to optimize cardiovascular health

This episode is a masterclass in heart disease prevention—don’t miss it.

Who is Dr. Michael Twyman

Dr. Twyman is a board-certified cardiologist specializing in early detection and prevention of cardiovascular disease. Founder of Apollo Cardiology in St. Louis, he’s recognized for integrating advanced arterial imaging, mitochondrial health strategies, and personalized medicine to optimize long-term heart health. Dr. Twyman’s mission is to educate his patients on how to live better and longer by optimizing their mitochondrial function to become heart attack proof.

This episode is brought to you by:

• Puori – Get 20% off sitewide with code DRLYON  → https://puori.com/DRLYON
• Ned – Get 15% off with code DRLYON → https://helloned.com/DRLYON
• LMNT – Get your free LMNT Sample Pack → https://drinklmnt.com/DRLYON
• Needed – Get 20% off your first order with code DRLYON  https://thisisneeded.com

Find Michael Twyman at:

• Website - https://drtwyman.com/
• Apollo Cardiology - https://drtwyman.com/apollocardiology/
• LinkedIn - https://www.linkedin.com/in/drtwyman/
• Instagram - https://www.instagram.com/drtwyman/
• X (Twitter) - https://x.com/michaeltwymanmd

Find Me At:

• Instagram:@drgabriellelyon  
• TikTok: @drgabriellelyon
• Facebook: facebook.com/doctorgabriellelyon
• YouTube: youtube.com/@DrGabrielleLyon
• X (Twitter): x.com/drgabriellelyon
• Apply to become a patient – https://drgabriellelyon.com/new-patient-inquiry/
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In this episode, I’m joined by journalist and author Michael Joseph Gross, whose book, Stronger: The Untold Story of Muscle in Our Lives, reveals the powerful and often overlooked role of muscle in human health and society—tracing its importance from ancient civilizations to modern science. We explore how our understanding of muscle has evolved through history, from symbols of strength and vitality in antiquity to current misconceptions in modern society. Michael shares insights from his extensive research, highlighting the incredible resilience of muscle tissue, debunking common myths about strength and aging, and providing compelling evidence for why everyone—no matter their age or background—should prioritize building and preserving muscle.

We cover:

• How muscle was viewed and valued from ancient cultures through modern times
• Why muscle mass is one of the strongest predictors of overall health and longevity
• How muscle acts as an endocrine organ influencing metabolism, immunity, and cognition
• The common misconceptions about strength training, especially in women and older adults
• How the science of muscle can change your approach to fitness and longevity
• The societal impact of muscle loss—and how we can turn it around

This conversation will leave you with a renewed appreciation for muscle—past, present, and future—and actionable insights to help you stay forever strong.

Who is Michael Joseph Gross?

Michael Joseph Gross is an accomplished journalist and author, widely recognized for his deeply researched, insightful explorations of human health and societal trends. His latest book, Stronger: The Untold Story of Muscle in Our Lives, delves into the transformative power of muscle from a biological, societal, and cultural perspective, offering groundbreaking insights into how muscle impacts our health, aging process, and overall quality of life.

This episode is brought to you by:

• MASA Chips – Get 25% off your first order → https://masachips.com/LYON
• OneSkin – Get 15% off with code DRLYON → https://oneskin.co
• MUD\WTR – Get up to 43% off with code DRLYON → https://mudwtr.com/DRLYON
• LMNT – Get your free LMNT Sample Pack → https://drinklmnt.com/DRLYON

Find Michael Joseph Gross at:

• Get the book:  https://www.michaeljosephgross.com/
• LinkedIn: https://www.linkedin.com/in/michael-joseph-gross-2937a5/
• Instagram: https://www.instagram.com/michaeljosephgross

Find Me At:

• Instagram:@drgabriellelyon  
• TikTok: @drgabriellelyon
• Facebook: facebook.com/doctorgabriellelyon
• YouTube: youtube.com/@DrGabrielleLyon
• X (Twitter):

In this episode, Dr. Alexis Wood, a leading researcher at Baylor College of Medicine, joins me to unpack insights into childhood nutrition, genetics, and cognitive health. Dr. Wood's work bridges genetics, dietary practices, and brain development, highlighting how early-life nutrition can shape lifelong outcomes. We explore cutting-edge research, practical strategies for parents, and the surprising factors influencing children's cognitive and metabolic health.

We cover:

• Why childhood nutrition and genetics have been historically overlooked—and what it means for your family.
• ADHD and diet: Separating fact from fiction.
• Debunking popular diet myths: What the research actually says about red meat and processed foods.
• Cognitive self-regulation: The hidden link between diet, obesity, and ADHD.
• Precision nutrition & metabolomics: The future is more than one-size-fits-all advice.

Whether you're a parent, educator, or health professional, this conversation offers guidance on navigating the complex relationship between nutrition, genetics, and childhood development.

Who is Dr. Alexis Wood?

Dr. Alexis Wood, Ph.D., F.A.H.A., is an Associate Professor of Pediatrics–Nutrition at Baylor College of Medicine’s USDA/ARS Children’s Nutrition Research Center. Her research integrates genetics, child development, and nutrition, focusing on how genetic factors influence responses to diet and behavior.

This episode is brought to you by:

• PaleoValley - Get 15% off at https://paleovalley.com/drlyon
• ARMRA – Use code DRLYON to get 15% off your first order at https://tryarmra.com/DRLYON
• Our Place - Use code DRLYON for 10% off sitewide – https://fromourplace.com/DRLYON
• Timeline - Get 20% off your order of Mitopure - https://timeline.com/LYON

Find Dr. Alexis Wood at:

• Linked In - https://www.linkedin.com/in/lekkiwood/
• Baylor College of Medicine - https://www.bcm.edu/people-search/alexis-wood-33281
• USDA/ARS Children's Nutrition Research Center - https://www.bcm.edu/research/research-centers/usda-ars-childrens-nutrition-research-center
• Alexis Wood Lab - https://www.bcm.edu/research/faculty-labs/alexis-lekki-wood-lab

Find Me At:

• Instagram:@drgabriellelyon  
• TikTok: @drgabriellelyon
• Facebook: facebook.com/doctorgabriellelyon
• YouTube: youtube.com/@DrGabrielleLyon
• X (Twitter): x.com/drgabriellelyon
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In this episode, I sit down with Dr. David Klurfeld—longtime USDA scientist and one of the few insiders to publicly challenge the WHO's classification of red meat as a carcinogen. We go deep into the flawed evidence behind the infamous 2015 IARC report, why nutritional epidemiology often fails to prove causality, and how a small group of researchers helped shape global policy with low-quality science. If you've ever felt confused about meat, saturated fat, or dietary guidelines, this conversation will help you think critically about what “counts” as evidence—and who gets to decide.

We cover:

• Dr. Klurfeld’s personal journey and lessons from a career in public health
• Why the 2015 IARC red meat classification was based on weak and inconsistent evidence
• How observational studies and “allegiance bias” mislead nutrition science
• The politics of dietary guidelines and the role of the USDA and WHO
• What the media got wrong—and why red meat remains a nutrient-dense food

Whether you're a clinician, dietitian, or simply trying to make better nutrition decisions, this episode is a powerful reminder that bias, groupthink and weak data can distort science and mislead the public. We need to be discerning about the nutrition and health advice we follow.

Who is Dr. David Klurfeld?

Dr. David Klurfeld is a nutritional scientist and former National Program Leader for Human Nutrition at the USDA’s Agricultural Research Service. He also served as Professor and Chair of Nutrition and Food Science at Wayne State University and Associate Editor of The American Journal of Clinical Nutrition. He has authored more than 200 scientific publications and was one of 22 experts invited to the 2015 IARC working group on red meat and cancer. He is a longtime advocate for scientific integrity in public health policy.

This episode is brought to you by:

• LMNT- Free Sample Pack with any purchase, visit https://DrinkLMNT.com/DRLYON
• Timeline - Get 20% off your order of Mitopure - https://timeline.com/LYON
• MUD\WTR - Use code DRLYON to get up to 43% off your starter kit - https://mudwtr.com/DRLYON
• Needed - Use code DRLYON for 20% off your first order - https://thisisneeded.com

Find Dr. David Klurfeld at:

• Indiana University Bloomington - https://publichealth.indiana.edu/about/directory/David-Klurfeld-dmklurfe.html
• Google Scholar - https://scholar.google.ca/citations?user=Ym5Og20AAAAJ&hl=en
• LinkedIn - https://www.linkedin.com/in/david-klurfeld-812845209/

Find me at:

• Instagram:@drgabriellelyon  
• TikTok: @drgabriellelyon
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Dr. Larry Lipshultz. is one of the world's leading experts in men's reproductive health. In this week's episode, we discuss testosterone therapy, male fertility, and the hidden environmental factors threatening men’s health. Dr. Lipshultz shares groundbreaking insights into why male fertility is declining, common myths surrounding testosterone and prostate cancer, and innovative strategies to safely enhance men's reproductive and overall health.

We cover:

• The alarming 50% drop in male fertility since the 1980s—and what’s driving it
• Testosterone therapy myths: prostate cancer, fertility, and what’s actually true
• Practical treatments for restoring fertility while on testosterone therapy
• Anabolic agents: risks, benefits, and smart use
• Personalized, patient-centered care to optimize male reproductive and overall health

If you care about men's health, fertility, or hormone optimization, this conversation is a must-listen.

Who is Dr. Larry Lipshultz?

Dr. Lipshultz’s research focuses on male reproductive dysfunction, testosterone therapy, cardiovascular risk, and the genetics of infertility. He has pioneered innovations in testicular sperm extraction, vasectomy reversal, and testosterone optimization therapies. With over 460 peer-reviewed publications and as co-author of a foundational textbook on andrology, his contributions have significantly enhanced diagnostic approaches in male infertility. An early recipient of the American Urological Association Research Scholar award, he advocates for integrative andrologic health as a foundation for lifelong wellness.

This episode is brought to you by:

• Puori - Get 20% off sitewide with Code DRLYON - https://Puori.com/DRLYON
• Cozy Earth - Use code DRLYON for up to 40% off - https://cozyearth.com
• Timeline - Get 20% off your order of Mitopure - https://timeline.com/LYON
• Manukora - Get $25 off the Starter Kit - https://manukora.com/DRLYON

Find Dr. Lipshultz at:

• Website - https://www.larrylipshultz.com/
• Baylor College of Medicine - https://www.bcm.edu/people-search/larry-lipshultz-25437
• LinkedIn - https://www.linkedin.com/in/larry-lipshultz-md-93977344/

Find Me At:

• Instagram:@drgabriellelyon  
• TikTok: @drgabriellelyon
• Facebook: facebook.com/doctorgabriellelyon
• YouTube: youtube.com/@DrGabrielleLyon
• X (Twitter): x.com/drgabriellelyon
• Apply to become a patient – https://drgabriellelyon.com/new-patient-inquiry/
• Join my weekly newsletter –

What if your biggest challenge isn’t motivation but missing structure? In this episode, I sit down with Brian Johnson to unpack the science and philosophy of lasting behavior change. We explore the power of ancient wisdom, stoicism, and the neuroscience of excellence, and why most wellness apps fail to deliver real transformation.

Brian shares his personal journey from startup success to creating a global movement around character, discipline, and identity-based habits. We talk about the science of anti-fragility, how muscle mirrors virtue, and why the gap between who you are and who you could be is the true source of suffering. Whether you're a high performer or someone who wants to stop breaking promises to yourself, this conversation will help you build the structure to show up as your best—no matter the circumstance.

What You’ll Learn:

• Why most behavior change fails—and what the science says works
• The philosophy of Areté: how to close the gap between potential and action
• How ancient stoicism aligns with modern recovery, resilience, and muscle
• Why building muscle is a metaphor (and mechanism) for building character
• The true definition of anti-fragility—and how to train it

If you're ready to bridge the gap between knowing and doing, this episode is the roadmap you've been looking for.

Who is Brian Johnson?

Brian Johnson has spent half of the last 25 years as a Founder/CEO and the other half as a Philosopher. As a Founder/CEO, he’s made crowdfunding history and built and sold two market-leading social platforms. As a Philosopher, he created Philosopher’s Notes, wrote the bestselling book Areté: Activate Your Heroic Potential, and developed a protocol integrating ancient wisdom, modern science, and practical tools that has been scientifically proven to help people change their lives. Brian is featured in the documentary Finding Joe on the modern Hero’s Journey and has trained some of the world’s most elite performers. He lives in the country outside of Austin with his wife and two kids and is all in on fulfilling Heroic’s mission to help create a more noble and virtuous world in which 51% of humanity is flourishing by 2051.

This episode is brought to you by:

• LMNT- Free Sample Pack with any purchase, visit https://DrinkLMNT.com/DRLYON
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• OneSkin - Use Code DRLYON for 15% off OneSkin – https:// www.oneskin.co
• Timeline - 20% off your order of Mitopure visit https://timeline.com/LYON

Find Brian Johnson at:

• Learn more about Brian Johnson and Heroic and get some free content just for my listeners: heroic.us/drlyon 
• Tiktok: https://www.tiktok.com/@heroicbrian
• Instagram: https://www.instagram.com/heroicbrian/
• Facebook: https://www.facebook.com/heroicbrian/
• Linkedin: https://www.linkedin.com/in/heroicbrian/
• YouTube:

When it comes to performance, more isn’t always better. In this episode, I sit down with conditioning expert Joel Jamieson to explore the science of recovery, aerobic fitness, and how to use heart rate variability (HRV) to train smarter. They dive into why elite athletes recover so quickly, the long-term value of zone 2 training, and how HRV reflects your resilience—not just your readiness. Joel shares lessons from two decades of working with fighters, Olympians, and NFL players, along with powerful insights from his own cardiovascular health journey. Whether you’re a high performer or simply want to live longer and stronger, this episode is packed with practical takeaways.

In this episode, you’ll learn:

• What HRV actually tells you—and what it doesn’t
• Why aerobic fitness is one of the strongest drivers of recovery and longevity
• The surprising downside of too much strength training
• How to monitor training load and avoid overtraining
• Why lifestyle stress matters more than your workout

This episode will change the way you think about training—and reveal why recovery deserves a central role in your performance strategy.

Who is Joel Jamieson?

Joel Jamieson is a leading coach and educator in recovery-based training and heart rate variability (HRV). With over 20 years of experience working with professional athletes, including NFL players and world champion fighters, he’s known for translating complex performance science into practical tools. He’s the creator of Morpheus, a system that helps tailor training to daily recovery status, and the founder of 8WeeksOut, a resource for conditioning and performance education.

This episode is brought to you by:

• Puori - Code DRYLYON to get 20% off sitewide - https://Puori.com/DRLYON
• MUD\WTR - Code DRLYON to get up to 43% off your starter kit - https://mudwtr.com/DRLYON
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Find Joel Jamieson at:

• Instagram: @coachjoeljamieson
• 8WeeksOut: https://8weeksout.com/
• Morpheus: https://trainwithmorpheus.com/

Find Me At:

• Instagram:@drgabriellelyon  
• TikTok: @drgabriellelyon
• Facebook: facebook.com/doctorgabriellelyon
• YouTube: youtube.com/@DrGabrielleLyon
• X (Twitter): x.com/drgabriellelyon
• Apply to become a patient – https://drgabriellelyon.com/new-patient-inquiry/
• Join my weekly newsletter –