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Latest Episodes
Essentials: Psychedelics for Treating Mental Disorders | Dr. Matthew Johnson
In this Huberman Lab Essentials episode, my guest is Dr. Matthew Johnson, PhD, a senior researcher for the Center of Excellence for Psilocybin Research and Treatment at Sheppard Pratt’s Institute for Advanced Diagnostics and Therapeutics.
We explore the science and therapeutic potential of psychedelic medicine, including psilocybin, MDMA and LSD. We discuss how these substances can profoundly alter perception and self-identity, providing long-lasting relief from depression, addiction and trauma when used in controlled clinical settings. We also discuss microdosing and emerging research on psychedelics’ potential to support recovery from neurological injuries.
Read the episode show notes at hubermanlab.com.
Thank you to our sponsors
AG1: https://drinkag1.com/huberman
David: https://davidprotein.com/huberman
BetterHelp: https://betterhelp.com/huberman
Timestamps
00:00:00 Matthew Johnson; Psychedelics
00:01:44 Different Classes of Psychedelics
00:04:33 Psychedelics & Altering Models
00:06:18 Sponsor: David
00:07:33 LSD, Psylocibin & Serotonin
00:09:55 Psychedelic Clinical Trials
00:13:40 Therapy, Trust, Psychedelics
00:16:47 Letting Go & Psychedelic Experience, Self-Representation, Lasting Changes
00:22:31 Sponsors: AG1 & BetterHelp
00:25:26 MDMA, Dopamine & Serotonin; Bad Trips & Transcendental Experience
00:28:49 Dangers of Psychedelics
00:31:11 Microdosing Psychedelics, Antidepressant
00:35:27 Head Injuries, Psychedelics, Depression
00:38:29 Acknowledgements
Disclaimer & Disclosures
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Health Effects & Risks of Kratom, Opioids & Other Natural Occurring Medicines | Dr. Chris McCurdy
My guest is Dr. Chris McCurdy, PhD, FAAPS, professor of medicinal chemistry at the University of Florida and a world expert on the pharmacology of kratom and other plant-derived medicinal compounds. We discuss kratom’s wide-ranging effects, including its use for boosting energy, enhancing mood, managing pain and as a potential opioid substitute, while also explaining its critical safety concerns and addictive potential, especially for kratom-derived/isolate products. We also discuss plant-based compounds more generally for their potential benefits and risks. Dr. McCurdy offers a balanced perspective on kratom and other plant-based and naturally occurring medicinal compounds, highlighting and contrasting their promise for human health with potential serious risks.
Read the episode show notes at hubermanlab.com.
Thank you to our sponsors
AG1: https://drinkag1.com/huberman
David Protein: https://davidprotein.com/huberman
Eight Sleep: https://eightsleep.com/huberman
ROKA: https://roka.com/huberman
Function: https://functionhealth.com/huberman
Timestamps
00:00:00 Chris McCurdy
00:02:51 Kratom (Mitragyna speciosa), Origin, Effects, Low vs High Doses
00:07:19 Sponsors: David Protein & Eight Sleep
00:10:07 Kratom, Traditional Use vs Commercial Kratom Products, Absorption
00:17:00 Kratom Products, Serving Size, Kids; Semi-Synthetics; Tool: Understand Kratom Product Labels
00:23:16 Kratom Products & Various Desired Effects; Physical Dependence
00:32:53 Different Kratom Usage Patterns, Opioid Dependence
00:36:59 Alkaloid Compounds, Nitrogen, Nicotine; Animals & Self-Experimentation
00:47:47 Sponsors: AG1 & ROKA
00:51:05 Medicine Development, Disconnection from Nature, Product Concentrations
00:59:00 Alkaloids & Natural Products, Opium Poppy, Coca Leaf, Tool: Kratom Leaf vs Extracts (Kratom-Derived/Kratom Isolates)
01:09:06 Is It Safe for Kids to Consume Kratom Products?
01:12:19 Kratom, Energy, Mood & Pain Management, Dose; Caffeine
01:16:56 Respiratory Depression & Kratom Products
01:20:16 Sponsor: Function
01:22:04 Kratom Leaf vs Derivatives, FDA Regulations, Usage Guidelines
01:26:59 Kratom, Alcohol Consumption, Respiratory Failure?
01:29:09 Kratom Alkaloids, Mood & Stimulant Effects, Multiple Pathways for Pain Relief
01:38:17 Plant Alkaloids & Chemical Defense, Kratom & Antifungal Alkaloids; Geckos
01:44:35 White, Red & Brown Vein Kratom, Leaf Processing; Terpenes
01:51:08 Kratom as an Anti-Depressant?; Discontinuing Kratom Use, Opioid Use
01:58:03 Kratom, Drug Interactions & Seizure, Opioids
02:01:51 Cacao Beans, Chocolate
02:09:34 Coca-Cola, Coca Plant & Cocaine, History of Soft Drinks
02:19:49 Career Journey, Pharmacy, Chemistry & Education, Lobelia
02:28:44 Nicotine; Natural Products & Career Journey, Salvia divinorum, Kratom
02:40:22 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter
Disclaimer & Disclosures
Learn more about your ad choices. Visit megaphone.fm/adchoices
In this Huberman Lab Essentials episode, I discuss both healthy eating and clinically recognized eating disorders, including anorexia, bulimia and binge eating disorder.
I explain how brain circuits, hormones such as leptin and reward systems interact to regulate appetite, satiety and overall eating behaviors. I also discuss the serious health risks associated with anorexia, explain how disrupted eating habits contribute to its development and highlight evidence-based treatments for anorexia. Finally, I explore binge eating and bulimia, discussing the underlying causes and the pharmacological treatments commonly used to support recovery.
Read the episode show notes at hubermanlab.com.
Thank you to our sponsors
AG1: https://drinkag1.com/huberman
LMNT: https://drinklmnt.com/huberman
Function: https://functionhealth.com/huberman
Timestamps
00:00:00 Eating Disorders
00:01:05 Fasting, Intermittent Fasting, Healthy Eating
00:06:10 Self-Diagnosis Caution
00:07:20 Sponsor: LMNT
00:08:52 Eating Disorders, Anorexia Nervosa
00:12:39 Hunger & Satiety; Appetite, Body Fat & Brain
00:17:20 Homeostasis & Reward Systems, Eating Disorders
00:21:12 Sponsor: AG1
00:22:49 Anorexia, Puberty, Hyperacuity & Food
00:25:55 Decision-Making vs Reflexes/Habits, Anorexia
00:29:29 Anorexia & Breaking Habits, Therapies & Family-Based Models
00:32:08 Distorted Self-Image & Anorexia
00:35:03 Sponsor: Function
00:36:43 Bulimia & Binge-Eating Disorder, Impulsivity & Prescription Treatments
00:40:28 Recap & Key Takeaways
Disclaimer & Disclosures
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How Nature & Other Physical Environments Impact Your Focus, Cognition & Health | Dr. Marc Berman
My guest is Dr. Marc Berman, PhD, a professor of psychology at the University of Chicago whose research explores how different physical environments—particularly nature and patterns found in nature—can positively impact our ability to focus, our cognitive performance and our mental and physical health. We discuss how our physical environment influences our attention, stress levels and brain and heart health. He explains how even brief periods in nature and exposure to natural images and sounds can restore and improve attentional capacity, reduce mental fatigue and help combat rumination and depression. Whether you live in a city, suburb or rural area, this episode offers simple science-backed strategies for incorporating nature and natural elements into your daily life to positively transform your cognitive ability and mental and physical health.
Read the episode show notes at hubermanlab.com.
Thank you to our sponsors
AG1: https://drinkag1.com/huberman
Helix Sleep: https://helixsleep.com/huberman
BetterHelp: https://betterhelp.com/huberman
Our Place: https://fromourplace.com/huberman
LMNT: https://drinklmnt.com/huberman
Timestamps
00:00:00 Marc Berman
00:02:14 Direct vs Involuntary Attention, Mental Fatigue, Attention Restoration Theory
00:06:59 Attention Fatigue, Focus & Vision, Tool: Restoring Attention in Nature
00:11:26 Sponsors: Helix Sleep & BetterHelp
00:13:50 Focused Work, Tool: Pre-Work Nature Breaks to Enhance Focus
00:15:54 Nature Walks & Cognitive Benefits, Comparing Nature vs Urban Environments
00:21:31 Nature, “Softly Fascinating Stimulation”, Fractals
00:27:12 Nature Images & Sounds, Cognitive Benefits
00:30:03 Urban vs Nature Images, Complexity & Image Compression; Semantics
00:40:44 Time Perception & Nature; Art Galleries
00:45:32 Tools: Resetting Attention & Nature Break; Features of a Restorative Nature Environments vs Focused Workspace; Length of Time in Nature
00:52:47 Sponsors: AG1 & Our Place
00:55:59 Nature, Time & Widening Attention; Fractals & Nature
01:02:21 Nature vs Urban Environments & Brain, Social Media & Attention
01:09:44 Depression & Rumination, Mental Well-Being, Attention & Nature
01:14:56 Sleep vs Wakefulness; Protecting Attention, Social Media
01:24:44 Sponsor: LMNT
01:26:19 Impulsivity, Texting & Attention, Meditation vs Nature Restoration
01:33:10 Passive Restorative vs Passive Depleting Activities, “Mental Obesity”, Shrinking Attention Span
01:37:31 Kids, Phones, Tool: Nature Free Play; Social Happy Hour, Tool: Solitary Nature Breaks
01:45:30 Physical Health Benefits of Nature, Trees & Indoor Greenery; Aquariums
01:53:26 Thoughts, Feelings & Physical Spaces, Biophilic Design, Bringing Nature Indoors
02:01:03 Nature Breaks, Incorporating Nature into Schools, Work, Home & Cities; Forest Bathing
02:09:18 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter
Disclaimer & Disclosures
Learn more about your ad choices. Visit megaphone.fm/adchoices
Essentials: Science of Stress, Testosterone, Aggression & Motivation | Dr. Robert Sapolsky
In this Huberman Lab Essentials episode my guest is Dr. Robert Sapolsky, PhD, a professor of biology, neurology and neurological sciences at Stanford University.
We discuss different types of stress and how our perception of stress as harmful or beneficial largely depends on context. He also explains how testosterone amplifies pre-existing behaviors and tendencies, and he highlights the crucial role of estrogen in supporting brain and body health. We also discuss daily cognitive practices for stress mitigation and how modern life, influenced by social media and complex social hierarchies, shapes our responses to stress.
Read the episode show notes at hubermanlab.com.
Thank you to our sponsors
AG1: https://drinkag1.com/huberman
Function: https://functionhealth.com/huberman
LMNT: https://drinklmnt.com/huberman
David: https://davidprotein.com/huberman
Timestamps
00:00:00 Robert Sapolsky
00:00:23 Positive & Negative Stress; Excitement, Amygdala
00:02:47 Testosterone & Brain, Aggression, Hierarchy
00:06:27 Sponsors: Function & LMNT
00:09:18 Testosterone, Motivation, Challenge & Confidence
00:13:52 Dopamine, Testosterone & Motivation
00:16:20 Estrogen, Brain & Health, Replacement Therapies
00:18:12 Stress Mitigation
00:22:09 Sponsors: AG1 & David
00:24:59 Cognitive Practices for Stress Mitigation, Individual Variability, Consistency
00:27:18 Stress, Perception & Individual Differences
00:29:39 Context, Stress & Brain
00:32:47 Social Media, Context, Multiple Hierarchies
00:35:57 Acknowledgments
Disclaimer & Disclosures
Learn more about your ad choices. Visit megaphone.fm/adchoices
How to Lose Fat & Gain Muscle With Nutrition | Alan Aragon
My guest is Alan Aragon, a renowned nutrition and fitness expert and researcher known for sharing the strongest evidence-based approaches to fat loss, muscle gain and overall health and fitness. We discuss how to optimize your protein intake, including how much to consume per meal and when, and the facts and myths about the “30-gram rule” and the “anabolic window” following exercise. We also discuss controversial topics such as seed oils, artificial sweeteners, animal vs. plant proteins, training fasted for fat loss and collagen supplementation. Alan Aragon clarifies the most important topics in nutrition and offers valuable time-saving yet extra-effective ways to exercise. He is a true expert in providing data-supported actionable exercise and nutrition protocols for anyone seeking to improve their body composition and health.
Read the episode show notes at hubermanlab.com.
Thank you to our sponsors
AG1: https://drinkag1.com/huberman
Carbon: https://joincarbon.com/huberman
Wealthfront**: https://wealthfront.com/huberman
David: https://davidprotein.com/huberman
Function: https://functionhealth.com/huberman
**This experience may not be representative of the experience of other clients of Wealthfront, and there is no guarantee that all clients will have similar experiences. Cash Account is offered by Wealthfront Brokerage LLC, Member FINRA/SIPC. The Annual Percentage Yield (“APY”) on cash deposits as of December 27, 2024, is representative, subject to change, and requires no minimum. Funds in the Cash Account are swept to partner banks where they earn the variable APY. Promo terms and FDIC coverage conditions apply. Same-day withdrawal or instant payment transfers may be limited by destination institutions, daily transaction caps, and by participating entities such as Wells Fargo, the RTP® Network, and FedNow® Service. New Cash Account deposits are subject to a 2-4 day holding period before becoming available for transfer.
Timestamps
00:00:00 Alan Aragon
00:02:17 Dietary Protein & Protein Synthesis Limits?, Tool: Post-Resistance Training & Protein Intake (30-50g)
00:09:16 Training Fasted, Post-Exercise Anabolic Window, Tool: Total Daily Protein
00:15:53 Daily Protein Intake, Timing & Exercise, Muscle Strength/Size
00:23:00 Sponsors: Carbon & Wealthfront
00:26:46 Does Fasted Training Increase Body Fat Loss?, Cardio, Individual Flexibility
00:36:53 Dietary Protein & Body Composition
00:38:58 Animal vs Plant Proteins (Whey, Soy, Pea, Quorn), Muscle Size & Strength
00:51:24 Sponsors: AG1 & David
00:54:14 Body Re-Composition, Gain Muscle While Losing Fat?, Tool: Protein Intake & Exercise
01:02:55 Fiber; Starchy Carbohydrates & Fat Loss, Ketogenic Diet
01:10:36 Inflammation, Fat & Macronutrients, Hyper-Palatability; Fish Oil Supplementation
01:16:52 Added Dietary Sugars, Sugar Cravings, Tool: Protein Intake
01:24:03 Artificial Sweeteners (Aspartame, Sucralose, Saccharine, Stevia), Diet Soda, Weight Loss
01:30:16 Sponsor: Function
01:32:04 Caffeine, Exercise & Fat Loss
01:34:53 Alcohol, Red Wine, Sleep, Lifestyle; Quitting Drinking & Stress Resilience
01:44:43 Seed Oils vs Animal Fats, Canola Oil, Olive Oil, Oil Production, Tool: Improve Diet Quality
01:55:50 Butter & Cardiovascular Risk, Saturated Fat, Mediterranean Keto Diet, Testosterone
02:00:43 Menstrual Cycle, Tool: Diet Breaks; Menopause Transition & Body Composition
02:07:04 Collagen Supplementation, Skin Appearance
02:12:44 Supplements: Multivitamins, Vitamin D3, Fish Oil, Creatine, Vitamin C
02:20:03 Resistance & Cardio Training, Tool: Cluster Sets & Super Sets
02:31:35 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter
Disclaimer & Disclosures
Learn more about your ad choices. Visit megaphone.fm/adchoices
Essentials: Understanding & Conquering Depression
In this Huberman Lab Essentials episode, I explore major depression, including its underlying biology and discuss science-based approaches to alleviate symptoms and improve mood.
I describe the wide-ranging symptoms of depression and explain how key neurotransmitters, hormones, stress, genetics and inflammation contribute to its development and persistence. I also cover treatment options, from traditional classes of antidepressant medications to emerging therapies such as ketamine and psilocybin. Finally, I highlight lifestyle-based tools, including exercise, supplementation and dietary strategies that can help manage depressive symptoms and promote mental well-being.
Read the episode show notes at hubermanlab.com.
Thank you to our sponsors
AG1: https://drinkag1.com/huberman
BetterHelp: https://betterhelp.com/huberman
Our Place: https://fromourplace.com/huberman
Timestamps
00:00:00 Major Depression
00:01:10 Depression Symptoms
00:06:14 Sponsor: BetterHelp
00:07:33 Pharmaceuticals for Depression, SSRIs; Norepinephrine, Dopamine & Serotonin
00:14:33 Thyroid Hormone, Cortisol, Stress & Depression, Menstrual Cycle, Genetics
00:17:43 Sponsor: AG1
00:19:20 Increase Norepinephrine, Tools: Deliberate Cold Exposure & Exercise
00:21:40 Chronic Inflammation & Depression, Tools: Omega-3s (EPA) & Exercise
00:26:49 Sponsor: Our Place
00:28:41 Tool: Creatine Monohydrate Supplementation & Improving Depression
00:30:20 Novel Depression Therapies, Ketamine, Psilocybin
00:35:29 Ketogenic Diet & Refractory Depression, GABA
00:37:57 Recap & Key Takeaways
Disclaimer & Disclosures
Learn more about your ad choices. Visit megaphone.fm/adchoices
The Chemistry of Food & Taste | Dr. Harold McGee
Dr. Harold McGee, PhD, is a renowned author on the topics of food chemistry and culinary science. He explains how cooking methods, types of cookware and temperature can be used to transform food and drink flavors and presents simple but powerful ways to improve nutrient availability. We also discuss how our individual biology, genetic and cultural backgrounds shape our taste preferences. Whether you’re a seasoned cook or someone who simply loves to eat, our conversation will change how you think about food and cooking, give you actionable tools to try and deepen your appreciation of the experience of eating and drinking.
Read the episode show notes at hubermanlab.com.
Thank you to our sponsors
AG1: https://drinkag1.com/huberman
Eight Sleep: https://eightsleep.com/huberman
Our Place: https://fromourplace.com/huberman
Mateina: https://drinkmateina.com/huberman
Function: https://functionhealth.com/huberman
Timestamps
00:00:00 Harold McGee
00:02:21 Food Chemistry, Using Copper, Modern vs Traditional Techniques
00:09:59 Sponsors: Eight Sleep & Our Place
00:13:33 Cooking, Food & Heat, Taste & Smell
00:22:10 Umami, Savory Tastes, Braising & Meat
00:29:56 Chemistry of Cooking & Eating, Sugars & Conjugates; Slowly Enjoying Food
00:36:14 Savory Meal & Dessert; Food Course Order; Palate Cleansers
00:43:56 Salt, Baseline & Shifting Taste Preferences
00:47:18 Sponsors: AG1 & Mateina
00:50:07 Whole vs Processed Foods, Taste & Enjoyment
00:53:37 Brewing Coffee, Water Temperature, Grind Size
01:00:33 Tea & Tannins, Growing Tea Plants; Tea & Meals, Polyphenols
01:08:16 Food Combinations, Individual Tolerance; Is there an Optimal Diet?
01:11:34 Onions & Garlic, Histamines, Tool: Reduce Crying when Cutting Onions
01:13:55 Gut Sensitivities & Food, Capsaicin & Spicy Foods
01:17:21 Supertasters & Taste Buds, Bitter Taste, Chefs
01:21:57 Sponsor: Function
01:23:45 Salt & Bitter, Salting Fruit, Beer or Coffee, Warming Beer
01:26:11 Human History of Alcohol & Chocolate
01:29:25 Wine Expense vs Taste, Wine Knowledge
01:35:49 Cheese Making, Aged Cheese & Crystals, Tyrosine; Smoke Flavors, Distilling
01:44:30 Fermentation, “Stink Fish”, Caviar, Traditional & New Foods
01:50:42 Personal Journey, Astronomy, Poetry & Food
01:54:55 Beans & Gas, Tool: Soaking Beans
01:57:23 Gut Microbiome, Fermented Foods; Kids & Food Aversions
02:00:47 Cilantro & Divergent Tastes; Microwave Popcorn, Parmesan Cheese
02:04:46 John Keats Poetry, To Autumn; Acknowledgements
02:10:48 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter
Disclaimer & Disclosures
Learn more about your ad choices. Visit megaphone.fm/adchoices
Essentials: Understanding & Treating Addiction | Dr. Anna Lembke
In this Huberman Lab Essentials episode, my guest is Dr. Anna Lembke, MD, Chief of the Stanford Addiction Medicine Dual Diagnosis Clinic at Stanford University School of Medicine.
We discuss how dopamine drives reward, motivation and addictive behaviors. Dr. Lembke explains the concept of the pleasure-pain balance of dopamine and how this cycle plays a key role in the development and persistence of addiction. We also discuss some of the challenges of addiction recovery, including withdrawal, relapses and the potential benefits of psychedelic-assisted therapy.
Read the episode show notes at hubermanlab.com.
Thank you to our sponsors
AG1: https://drinkag1.com/huberman
Wealthfront**: https://wealthfront.com/huberman
BetterHelp: https://betterhelp.com/huberman
**This experience may not be representative of the experience of other clients of Wealthfront, and there is no guarantee that all clients will have similar experiences. Cash Account is offered by Wealthfront Brokerage LLC, Member FINRA/SIPC. The Annual Percentage Yield (“APY”) on cash deposits as of December 27, 2024, is representative, subject to change, and requires no minimum. Funds in the Cash Account are swept to partner banks where they earn the variable APY. Promo terms and FDIC coverage conditions apply. Same-day withdrawal or instant payment transfers may be limited by destination institutions, daily transaction caps, and by participating entities such as Wells Fargo, the RTP® Network, and FedNow® Service. New Cash Account deposits are subject to a 2-4 day holding period before becoming available for transfer.
Timestamps
00:00:00 Anna Lembke
00:00:15 Dopamine, Reward & Movement
00:01:54 Baseline Dopamine; Genetics, Temperament & Addiction
00:05:24 Addiction, Modern Life & Boredom
00:07:18 Sponsor: AG1
00:08:55 Pleasure-Pain Balance, Dopamine, Addiction
00:14:17 Resetting Dopamine, Substance or Behavior Recovery, Tool: 30-Day Abstinence
00:16:04 Relapse, Addiction, Reflexive Behavior, Empathy
00:20:17 Triggers, Relapse, Dopamine
00:23:15 Sponsor: Wealthfront & BetterHelp
00:26:04 Shame, Truth Telling & Recovery
00:28:26 Addiction, Psychedelic-Assisted Therapy, Psilocybin, MDMA
00:33:29 Social Media & Addiction, Tool: Intentionality
Disclaimer & Disclosures
Learn more about your ad choices. Visit megaphone.fm/adchoices
Bio of Huberman Lab
Huberman Lab, an enlightening podcast presented by Scicomm Media. In this podcast, the fascinating world of neuroscience takes center stage as discussions revolve around how the brain and its intricate connections with the body's organs shape our perceptions, behaviors, and overall health.
The podcast also delves into the tools and techniques used to measure and modulate the functioning of the nervous system.
Leading the conversations in Huberman Lab is Dr. Andrew Huberman, a tenured professor of neurobiology and ophthalmology at Stanford School of Medicine. Dr. Huberman's research focuses on neural regeneration, neuroplasticity, and various brain states such as stress, focus, fear, and optimal performance. With a distinguished career spanning over two decades, he has consistently published original research findings and review articles in esteemed peer-reviewed journals, including Nature, Science, Cell, Neuron, and Current Biology.
Dr. Huberman's expertise has led to his involvement as a regular member of National Institutes of Health review panels and recognition as a Fellow of the McKnight Foundation and the Pew Charitable Trusts. He also serves as a consultant for technology development companies, professional athletic organizations, and specialized units of U.S. and Canadian Special Operations.