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Latest Episodes
Collin West - Rowing across the Arctic, Near Death Experiences, and Venture Capital
Join Boost VC’s Adam Draper as he chats with Collin West, founder of Ensemble VC, about his incredible journey rowing across the Arctic Ocean and how it changed his approach to decision-making and team management. Learn how this experience influences Ensemble’s data-driven approach to assessing startups. Adam and Collin dive into the evolution of venture capital and reflect on their near-death experiences. Tune in for laughs, insights, and a fresh perspective on adventure and opportunity in VC!
Collin is the Founder and Managing Partner of Ensemble VC, which focuses on using data to identify top teams building companies that can impact a billion people. Collin is also a Guinness World Record holder for leading the first-ever crossing of the Arctic Ocean. His team of four rowed non-stop and unsupported for 41 days through the biggest storm season in Arctic history - this is where he learned just how important a great team is pursuing a mission that's never been done before. Collin's prior investments include Zoom Video (NASDAQ: ZM), Carta, Groww, ICON, Saronic, Sidecar Health, and many others. Previously, Collin was a founder of the Kauffman Fellows VC fund and on the founding fund team at the pioneering data-driven VC firm Correlation Ventures. An avid competitor, Collin spends his free time training Brazilian jiu-jitsu, mountain biking, and climbing mountains.
Connect with Collin West
Ensemble VC https://www.ensemble.vc/home/#ensemble
Ensemble VC on LinkedIn https://www.linkedin.com/company/ensemblevc/
Collin on LinkedIn https://www.linkedin.com/in/collinwest/
Collin on Instagram https://www.instagram.com/collinrwest/?hl=en
Connect with Boost VC
Boost VC LinkTree https://linktr.ee/boostvc
Bringing Scientific Expertise to the VC Market—with Arkady Kulik of RPV
According to a BCG report, only 19% of VCs have some kind of scientific or technological competence. And that creates a translation problem between deep tech founders and investors.
To close that gap, Arkady Kulik and his cofounder, Tamaz Khunjua, built RPV, a venture fund that brings scientific expertise to the market and helps scientists become strong entrepreneurs.
On this episode of The Boost VC Podcast, Arkady joins us to explain how the RPV team’s extensive background in science and entrepreneurship serves deep tech startups.
Arkady describes how starting a venture fund differs from founding other companies and shares his excitement around ‘being at the edge of science’ as a frontier tech VC.
Listen in for Arkady’s unique take on what it means to be useful to others and learn how RPV is working to make talented scientists billionaires!
Topics Covered
The idea behind RPV
- Help scientists become strong entrepreneurs
- ‘Commercialization of science’
How Arkady got into venture capital
- Moved to US to be part of scientific exploration of humanity
- Lack of funding in prototyping stage of deep tech startups
Arkady’s biggest accomplishment before age 20
- Launched first company at 18 without external investment
- Scaled to annual revenue of $5M in third year
How starting a venture fund differs from starting other companies
- More competitive, thousands of similar funds raising money
- Harer to differentiate and properly tell story of niche
What part of being a VC Arkady enjoys the most
- Being at edge of science and meeting interesting people
- Finding processes that make things work
The secret skills Arkady is most proud of
- Developed extreme level of discipline
- Extremely organized in managing time and data
How Arkady thinks about being useful to others
- Provide with relevant information or connections
- Put smile on someone’s face, make life better
The most valuable thing RPV provides for deep tech startups
- External proof point for science and technology
- Entrepreneurial experience and change management
Arkady’s ‘deathbed test’ to measure success
- Nothing ‘could have but didn’t achieve’
- Self-actualization (happy, complex person)
Connect with Arkady Kulik
RPV on LinkedIn https://www.linkedin.com/company/rpvglobal/
Arkady on LinkedIn https://www.linkedin.com/in/arkady-kulik/
Arkady on X https://twitter.com/arkadykulik
Resources
Starburst Aerospace https://starburst.aero/
Cantos VC https://cantos.vc/
Countdown https://countdown.capital/
Fifty Years https://fiftyyears.com/
Productivity Planner https://www.intelligentchange.com/products/productivity-planner
Terraforming Mars https://www.fryxgames.se/games/terraforming-mars/
Breakfast with Pops: A Venture Capital Handbook by Adam Draper and William H. Draper III https://www.amazon.com/Breakfast-Pops-Venture-Capital-Handbook/dp/B0C1JHXTQF
Connect with Boost VC
Boost VC Website https://www.boost.vc/
Boost VC on Facebook https://www.facebook.com/boostvc/
Boost VC on X https://twitter.com/BoostVC
Boost VC on Instagram https://www.instagram.com/boost_vc/
DeepTech Series Ep # 4: Betting on Mission-Driven Deep Tech—with Maryanna Saenko of Future Ventures
If a VC is excited about a deep tech company upfront, what can we do to temper our enthusiasm and make a rational decision on whether to invest?
Maryanna Saenko is Cofounder and Partner at Future Ventures, an early-stage VC firm that focuses on mission-driven companies at the cutting edge of disruptive technology.
Future Ventures looks to back visionaries who push the boundaries of possibility. Some of their recent investments include Beeflow, Deep Genomics and Earthshot Labs.
On this episode of Boost VC, Maryanna joins us to share her definition of deep tech, describing how Future Ventures looks for opportunities ‘unlike anything we’ve ever seen before.’
Maryanna offers her take on why the two-person structure of a venture firm is ideal and discusses some of the deep tech deals she wishes she’d been closer to.
Listen in for Maryanna’s insight on building organizations around big shifts in science or technology and learn her process for dialing down the excitement after a pitch to decide whether her YES will hold.
Topics Covered
Maryanna’s biggest accomplishments before age 20
- Recognized she wouldn’t survive public high school
- Got into Hopkins prep school on scholarship
How Maryanna got into venture capital
- Worked for early-stage company out of college
- Job offer from Daimler to figure out driverless cars
- Introduced to head of innovation lab at Airbus
The most important lessons Maryanna has learned as a VC
- Trust your intuition
- Don’t waste time justifying a startup’s relevance
How Maryanna defines deep tech
- ‘Unlike anything we’ve ever seen before’
- Index on novelty at Future Ventures
What Maryanna does when she’s all-in on a company right away
- Asks what she must believe about reality for YES to hold
- Discussion with partner to temper her excitement
Why Maryanna prefers the two-person structure in venture
- Ideal for its efficiency and intellectual honesty
- Never puts someone in tie-breaker position
Maryanna’s superpowers as a venture investor
- Confident in ability to assess tech on first principles
- Know how to build orgs around shifts in science or tech
What deals Maryanna wishes she had been closer to
- Structure of open AI
- Deep seabed mining, recycling battery technology
Maryanna’s definition of success
- Feel landscape of possibility was totally exhausted
- ‘Everything I could give to this, I did’
Connect with Maryanna Saenko
Future Ventures https://future.ventures/
Future on Facebook https://www.facebook.com/FutureVenturesVC
Future on Instagram https://www.instagram.com/future.ventures/
Future on LinkedIn https://www.linkedin.com/company/futureventures/
Maryanna on LinkedIn https://www.linkedin.com/in/maryannasaenko/
Maryanna on Twitter https://twitter.com/FutureSaenko
Resources
Lux Research https://www.luxresearchinc.com/
DARPA Grand Challenge https://www.darpa.mil/about-us/timeline/-grand-challenge-for-autonomous-vehicles
Airbus BizLab https://www.airbus.com/en/innovation/innovation-ecosystem/airbus-bizlab
Beeflow https://www.beeflow.com/
Decoding the World by Po Bronson and Arvind Gupta https://www.amazon.com/Decoding-World-Questioner-Po-Bronson/dp/1538734311
Redwood Materials https://www.redwoodmaterials.com/
American Prometheus: The Triumph and Tragedy of J. Robert Oppenheimer by Kai Bird and Martin J. Sherwin https://www.amazon.com/American-Prometheus-audiobook/dp/B000OZ0J0W/
Connect with Boost VC
Boost VC Website https://www.boost.vc/
Boost VC on Facebook https://www.facebook.com/boostvc/
Boost VC on Twitter https://twitter.com/BoostVC
Boost VC on Instagram https://www.instagram.com/boost_vc/
DeepTech Series Ep # 3: What to Look for in a Deep Tech Founder—with Greg Castle of Anorak Ventures
Deep tech founders are either technically gifted or great at building a business. But it's seldom both, at least in the beginning.
So, what should venture investors pay attention to when we’re choosing founders in these disruptive technologies?
Greg Castle is Founder and Managing Director at Anorak Ventures, a firm that invests in early-stage deep tech startups.
An entrepreneur and corporate marketer turned VC, Greg has invested in 120 companies, including Oculus, Flexport and Mux.
On this episode of Boost VC, Greg joins us to explore how his view of venture investing has changed since he wrote his first check, explaining what he looks for in a founder and how he evaluates deep tech startups differently.
Greg shares his mixed feelings about the VR market right now and how he benefits from having a partner to engage in conviction-based decision-making.
Listen in for Greg’s advice on where to deploy capital in deep tech and learn how Anorak chooses founders who apply disruptive technologies to business problems in any industry.
Topics Covered
How Greg got into venture capital
- Curious person who advocates for people he believes in
- Got lucky in first few personal investments, e.g.: Oculus
The most important lessons Greg has learned as a VC
- What high-functioning teams and companies look like
- Not to take it personally when things don’t go as planned
What Greg pays attention to when he’s choosing founders
- How they interact with cofounders, react to feedback
- Punctuality at meetings, preparedness and responsiveness
The questions Greg asks himself before he invests in a startup
- Do I believe in the founder?
- Do I believe in the market?
How Greg evaluates deep tech companies differently
- Move forward with presumption that anything’s possible
- Consider if technically gifted person can build business
Greg’s mixed feelings about the VR market right now
- Viable platform where developers make real money
- Frustrated by lack of competition, Meta fumbling the ball
Greg’s thoughts on Apple entering the VR/AR market
- ‘Nobody can make a product cool like Apple can’
- Not well-positioned in immersive gaming (primary use case)
The Anorak investment thesis
- Handful of technologies will have outsized impact on future
- Find teams leveraging those technologies, industry agnostic
Greg’s advice on where to deploy capital in deep tech
- Always comes down to people
- Build out ecosystem of investors, founders
How Greg thinks about scale in venture investing
- Find great people in areas that are not your strengths
- Scale of funds = $15M to $25M per partner
How Greg benefits from taking on a partner
- Need to explain yourself to thought partner
- Can still move quickly when he needs to
Greg’s biggest accomplishments before age 20
- Building group of friends in college
- Still works with many of them
Greg’s definition of success
- Confident and comfortable in your own skin
- Content with what you have
Connect with Greg Castle
Anorak Ventures https://www.anorak.vc/
Anorak on Medium https://anorakvc.medium.com/
Anorak on Twitter https://twitter.com/AnorakVentures
Anorak on LinkedIn https://www.linkedin.com/company/anorak-ventures/
Greg on LinkedIn https://www.linkedin.com/in/gregorycastle/
Greg on Twitter https://twitter.com/gpcastle12
Resources
Greg Castle on Boost VC EP001 https://www.youtube.com/watch?v=2PyO3LpZD9Q
Greg Castle on Boost VC EP089 https://open.spotify.com/episode/6qYRcDMoemjrMHDxKONu4A
Oculus https://www.meta.com/quest/
GOLF+ https://www.golfplusvr.com/
FitXR https://fitxr.com/
Neverwhere by Neil Gaiman https://www.amazon.com/Neverwhere-Novel-Neil-Gaiman-ebook/dp/B000FC130E
Snow Crash by Neal Stephenson https://www.amazon.com/Snow-Crash-Novel-Neal-Stephenson-ebook/dp/B000FBJCJE/
Hyperion by Dan Simmons https://www.amazon.com/Hyperion-Cantos-Book-1-ebook/dp/B004G60EHS/
Neuromancer by William Gibson https://www.amazon.com/Neuromancer-Sprawl-Trilogy-William-Gibson-ebook/dp/B000O76ON6/
Breakfast with Pops: A Venture Capital Handbook by Adam Draper & William Henry Draper, III https://www.amazon.com/Breakfast-Pops-Venture-Capital-Handbook/dp/B0C1JHXTQF
‘Perception Is Reality’ Presentation https://www.anorak.vc/post/perception-is-reality-8-startup-marketing-principles
Connect with Boost VC
Boost VC Website https://www.boost.vc/
Boost VC on Facebook https://www.facebook.com/boostvc/
Boost VC on Twitter https://twitter.com/BoostVC
Boost VC on Instagram https://www.instagram.com/boost_vc/
DeepTech Series Ep # 2: Thesis Development for Deep Tech—with Seth Winterroth of Eclipse Ventures
How does a venture firm approach investments in deep technology?
Seth Winterroth is Partner at Eclipse Ventures, a VC firm that partners with exceptional entrepreneurs to build companies that redefine physical industries.
Seth has nine years of experience in venture capital, serving as Associate at GE Ventures before he joined the team at Eclipse.
On this episode of Boost VC, Seth joins us to explore how Eclipse thinks about investing in emerging technologies, explaining how the team engages with customers and leverages internal expertise to identify high-magnitude market opportunities.
Seth shares his interest in robotics, discussing why the acquisition of Kiva Systems sparked his interest in this particular deep tech field and how he identified the opportunity to invest in 6 River Systems—the first deal he led at Eclipse.
Listen in for Seth’s advice to young VCs on cultivating patience and responding to chaos with calm, engaging with founders in a way that’s rational and devoid of fear.
Topics Covered
The thesis at Eclipse Ventures
- Small teams of engineers solving hard development problems
- Industries that operate in physical world (80% of global GDP)
How Seth thinks about investing in emerging technology
- Start with markets, customer pain points
- Find specialist to develop n-of-1 solution
- Add traditional engineers with experience scaling technology
What gets Seth excited about robotics
- Kiva Systems acquisition by Amazon sparked interest
- Saw market trends driving adoption of autonomous systems
The success of Seth’s first investment at Eclipse, 6 River Systems
- Robotics company in supply chain logistics
- Acquired for $500M by Shopify in 2019
How Seth identified the opportunity to invest in 6 River Systems
- Ideal team profile and product differentiation
- Gap in market to replace Kiva Systems
Eclipse’s institutional process of thesis development
- Engage with customers, purchasing decision-makers
- Internal engineering expertise to identify gaps
Eclipse’s internal venture equity program
- Cases where did research but didn’t find right opportunity
- Engineer storm vs. wait for lightning to strike
What Eclipse does to win deals
- Build relationships with founders
- Provide evidence of value-added capital
The part of a deal Seth is most excited about
- Find high-magnitude market opportunity to match worldview
- Go to partners with conviction and say THIS ONE
What Seth would tell his 25-year-old self
- Be patient, don’t rush to have track record in venture
- Respond to chaos with calm, be rational and devoid of fear
What differentiates Eclipse from other venture firms
- Tackle category of economy traditional VCs shy away from
- Deep involvement with companies to improve odds
Seth’s biggest accomplishments before age 20
- Live on own and travel world
- Spend meaningful time with and learn from grandfather
Connect with Seth Winterroth
Eclipse Ventures https://eclipse.vc/
Eclipse on LinkedIn https://www.linkedin.com/company/eclipse-vc/
Eclipse on Twitter https://twitter.com/eclipseventures
Seth on Twitter https://twitter.com/Sethwinterroth
Seth on LinkedIn https://www.linkedin.com/in/sethwinterroth/
Resources
Kiva Systems Acquisition https://techcrunch.com/2012/03/19/amazon-acquires-online-fulfillment-company-kiva-systems-for-775-million-in-cash/
Willow Garage https://www.businessinsider.com/a-look-back-at-willow-garage-2016-2
DARPA Grand Challenge https://www.darpa.mil/about-us/timeline/-grand-challenge-for-autonomous-vehicles
6 River Systems https://6river.com/
Bright Machines https://www.brightmachines.com/
BrightInsight https://brightinsight.com/
Foxglove Studio https://foxglove.dev/
Kevin Kelly’s Blog ‘You Are Not Late’ https://medium.com/message/you-are-not-late-b3d76f963142
Richard Hamming’s Talk ‘You and Your Research’ https://www.youtube.com/watch?v=a1zDuOPkMSw
Team of Rivals: The Political Genius of Abraham Lincoln by Doris Kearns Goodwin https://www.amazon.com/Team-Rivals-Political-Abraham-Lincoln/dp/0743270754
Lincoln https://www.imdb.com/title/tt0443272/
Connect with Boost VC
Boost VC Website https://www.boost.vc/
Boost VC on Facebook https://www.facebook.com/boostvc/
Boost VC on Twitter https://twitter.com/BoostVC
Boost VC on Instagram https://www.instagram.com/boost_vc/
DeepTech Series Ep # 1: Making Global-Scale Impact Through Deep Tech—with Ian Rountree of Cantos
What inspires a venture firm to focus on deep tech?
Ian Rountree is Founder and General Partner at Cantos, a venture fund that invests in potentially world-changing deep tech startups.
Cantos focuses on hardware and bio investing at the intersection of climate and industrials, life sciences and AI, aerospace and defense, and next-generation computing.
On this episode of Boost VC, Ian joins us to share his definition of deep tech and explain why he underwrites technical risk rather than market risk.
Ian discusses the value of founder empathy, challenging VCs to see the entrepreneur as their customer and LPs as shareholders in the portfolio.
Listen in to understand what drives Ian to make a global-scale impact, backing founders who tackle climate change, disease, armed conflict, poverty and existential risk.
Topics Covered
Ian’s biggest accomplishment before age 20
- Getting Vanderbilt to accept him off waitlist
- Refused to take NO as answer
Ian’s take on who is the customer in venture capital
- Founder = customer
- LP = shareholder
What inspired Ian to focus on deep tech
- Tackle big problems, e.g.: climate change, poverty
- Deep tech startups outperformed rest of portfolio
How losing his father early informs Ian’s work
- Feels hard deadline to career and life
- Wants to play small role in changing world
The criteria Ian uses to decide if a startup is ‘important’
- Nonzero chance of global-scale impact
- Tackles climate, disease, armed conflict or poverty
How Ian defines deep tech
- Taking technical risk rather than market risk
- Cantos specializes in hardware and bio investing
How Ian thinks about growing the Cantos organization
- From solo GP to 4 equal partners
- ‘Fire’ himself by age 55
What’s behind Benchmark’s equal partnership structure
- Set up for generational turnover from jump
- May also be consequence of early success
Why a deep tech VC doesn’t need to be technical
- Ask expert if violation of physics involved
- Startups that change world challenge status quo
What differentiates software investing from deep tech
- Software involves market risk, easy to pivot
- Deep tech involves technical risk, hard to pivot
Ian’s diligence criteria
- Size of market, potential margins at scale
- Founder who understands their WHY
Connect with Ian Rountree
Cantos https://cantos.vc/
Cantos on Twitter https://twitter.com/cantos
Ian on Twitter https://twitter.com/ianrountree
Ian on LinkedIn https://www.linkedin.com/in/ianrountree/
Near Frontier Podcast https://nearfrontier.castos.com/
Resources
Fred Wilson’s Blog ‘The VC’s Customer’ https://avc.com/2005/11/the_vcs_custome/
Fred Wilson’s Blog ‘The VC’s Customer (Continued)’ https://avc.com/2009/07/the-vcs-customer-continued/
Radiant https://www.radiantnuclear.com/
Tim Urban’s TED Talk on Procrastination https://www.ted.com/talks/tim_urban_inside_the_mind_of_a_master_procrastinator/c
Benchmark https://www.benchmark.com/
eBoys: The First Inside Account of Venture Capitalists at Work by Randall E. Stross https://www.amazon.com/eBoys-Inside-Account-Venture-Capitalists/dp/0812930959
Benchmark Part I on the Acquired Podcast https://www.acquired.fm/episodes/benchmark-capital
Benchmark Part II on the Acquired Podcast https://www.acquired.fm/episodes/benchmark-part-ii-the-dinner
Union Square Ventures https://www.usv.com/
Cerebras https://www.cerebras.net/
Eric Vishria on Twitter https://twitter.com/ericvishria
Connect with Boost VC
Boost VC Website https://www.boost.vc/
Boost VC on Facebook https://www.facebook.com/boostvc/
Boost VC on Twitter https://twitter.com/BoostVC
Boost VC on Instagram https://www.instagram.com/boost_vc/
DeSci Ep # 7: How DeSci Bridges Academia and the Startup World—with Niklas Rindtorff of LabDAO
Many independently minded, young scientists are too ambitious for academia… But the startup world isn’t quite right for them either.
How might decentralized science provide a space for these innovators to do their work?
Niklas Rindtorff is the classical scientist behind LabDAO, an online home for inventors that builds open tools for scientific research. Niklas coauthored his first paper before the age of 20, and he has expertise in CRISPR and cancer research.
On this episode of Boost VC, Niklas joins us to explain how classical science emerged after World War II and explore the problems with the NIH grant funding process.
Niklas shares his open-access approach to consuming scientific media and describes how DeSci is experimenting with different ways to measures the importance of new science.
Listen in to understand how decentralized science can serve as the bridge between research organizations and science startups, building an ecosystem for inventors who don’t fit into the nonprofit or for-profit world.
Topics Covered
How Niklas defines science
- Formal knowledge generation process
- Fishing at edge of what is known
How World War II changed the way we do science
- Conflict won because of US sophisticated tech
- NIH funding created class of full-time scientists
- System doesn’t always maximize progress
How the importance of new science is determined
- Measured by citations vs. markets
- DeSci experiments with different accounting
How Niklas consumes scientific media
- Used to use few free, open-access journals
- Now leverage Twitter bookmarks, preprints
What LabDAO does for scientists
- Provide tools to work wherever they are
- Current focus on computational biology
What inspired Niklas to build LabDAO
- Experience with inventions stuck in bureaucracy
- Measure number of patients treated vs. citations
The age distribution of NIH grant recipients
- Ages with scientists who were first
- No market discipline, don’t answer to public
How we might equalize the demographic of NIH winners
- Create more NIHs
- Private funding agency with philanthropic match
How we might invest in a portfolio of science
- Charge higher fee to run research-oriented fund
- Online collectives do research sponsorships
How LabDAO itself is funded
- Nonprofit governed by token
- Private investors buy token for stake on projects
The relationship between academia and DeSci
- Connective tissue among existing organizations
- Inventors who don’t fit in academia or startups
Niklas’ definition of success
- Strive toward personal values
- Invent cool stuff
Connect with Niklas RIndtorff
LabDAO https://www.labdao.xyz/
LabDAO on Discord https://discord.com/invite/labdao
LabDAO on GitHub https://github.com/labdao
LabDAO on Snapshot https://snapshot.org/#/labdao.eth
LabDAO on Medium https://medium.com/@labdao
LabDAO on Twitter https://twitter.com/lab_dao
Niklas on Twitter https://twitter.com/niklas_tr
Resources
Broad Institute https://www.broadinstitute.org/
‘Science the Endless Frontier’ 1945 Report to Congress https://www.nsf.gov/od/lpa/nsf50/vbush1945.htm
National Institutes of Health https://www.nih.gov/
Public Library of Science https://plos.org/
bioRxiv https://www.biorxiv.org/
New Science https://newscience.org/
VitaDAO https://www.vitadao.com/
Connect with Boost VC
Boost VC Website https://www.boost.vc/
Boost VC on Facebook https://www.facebook.com/boostvc/
Boost VC on Twitter https://twitter.com/BoostVC
Boost VC on Instagram https://www.instagram.com/boost_vc/
DeSci Ep # 6: Commercializing Science for Climate Solutions—with George Church & Ben Lamm of Colossal
In academia, most scientists publish their ideas and stop there. But if we want our breakthroughs to benefit society, we have to take it a step further.
So, what does it look like to commercialize scientific research? What mindset do academics need to work at the intersection of science and industry?
Ben Lamm has a career of building successful deep tech businesses, and George Church has a career of commercializing academic science.
Together, they are the cofounders of Colossal, a breakthrough bioscience and genetic engineering company that is pioneering animal de-extinction technology to restore lost ecosystems for a healthier planet.
On this episode of Boost VC, Ben and George join us to explain how bringing back the woolly mammoth addresses climate change and explore their approach to the ethical concerns around de-extinction.
They discuss the benefits of Colossal technology beyond Arctic rewilding, describing how their work helps endangered animals and promotes conservation.
Listen in for Ben and George’s insight on commercializing science and learn how to get comfortable enough with risk to turn academic ideas into industry.
Topics Covered
How George defines science
- Predict and create new options for humanity
- Goal to build better world
Why Ben & George are bringing back the woolly mammoth
- Restore previous ratio of grass to trees
- Sequester carbon at rate only possible in Arctic
How Ben & George approach the ethical concerns re: de-extinction
- Believe in radical transparency
- Learn from negative feedback, people who question
Why George works at the intersection of academia and industry
- Likes to work with curious young people
- Exposure to diversity of ideas
Why Colossal needs government collaboration and support
- Several governments, Indigenous groups in Arctic
- Climate change, biodiversity and species preservation
How woolly mammoths promote carbon removal
- Knock down trees so more grass can grow
- Cold, Arctic grasslands sequester carbon particularly well
The benefits of Colossal technology beyond Arctic rewilding
- Eradicate EHV virus in elephants
- Promote species conservation
How Ben & George think about commercializing science
- Go beyond publication to help society
- Feedback from investors and academia
What makes Ben & George’s partnership work
- George’s lab provides idea from academic study
- Ben figures out product-market fit and funding
George’s advice to academics on commercializing products
- Can’t be afraid of failure
- Can come back from bankruptcy
How Ben & George think about taking big risks
- Ben believed grandmother saying he could do anything
- Academic failures taught George he would survive
The impact Ben & George hope to make with Colossal
- Ex utero development, species preservation
- Thousands of Arctic elephants to sequester carbon
- Advancements in reading and writing of genomes
How Ben & George define success
- Benefit society, facilitate survival of species
- Create things that are additive
Connect with George Church & Ben Lamm
Colossal https://colossal.com
Colossal on Twitter https://twitter.com/ItIsColossal
Colossal on Facebook https://www.facebook.com/itiscolossal/
Colossal on Instagram https://www.instagram.com/itiscolossal/
George on Twitter https://twitter.com/geochurch
Ben on Twitter https://twitter.com/federallamm
Resources
Citizen Science https://www.citizenscience.gov/#
Personal Genome Project https://www.personalgenomes.org/
How to Grow (Almost) Anything https://www.media.mit.edu/courses/htgaa/
DIYbio https://diybio.org/
Church Lab https://arep.med.harvard.edu/
Hypergiant https://www.hypergiant.com/
Pleistocene Park https://pleistocenepark.ru/
Chris Mason Author Talk https://mitpress.mit.edu/blog/author-talk-the-next-500-years-by-christopher-e-mason/
Prehistoric Planet https://tv.apple.com/us/show/prehistoric-planet/umc.cmc.4lh4bmztauvkooqz400akxav
Connect with Boost VC
Boost VC Website https://www.boost.vc/
Boost VC on Facebook https://www.facebook.com/boostvc/
Boost VC on Twitter https://twitter.com/BoostVC
Boost VC on Instagram https://www.instagram.com/boost_vc/
DeSci Ep #5: An Investor’s Perspective on DeSci—with James Sinka of Orange DAO
Why invest in decentralized science?
James Sinka is a classically trained chemist and materials engineer and DeSci investor at Orange DAO, a fund for crypto projects supported by an alliance of Y Combinator alumni.
On this episode of Boost VC, James joins us to discuss where he sees opportunities in DeSci, describing the benefit of publishing null results and how open science helps us get to the truth more quickly.
James explains how the Orange Fund and Orange DAO work together to finance crypto projects and shares his advice to scientist-founders on generating your own luck through action.
Listen in for James’ insight on the first use cases for decentralized science and learn how investing in DeSci can democratize access to research and help rebel scientist-entrepreneurs ship products in the real world!
Topics Covered
How James defines science
- Process to uncover truths about world
- Not an institution of truth
What attracted James to DeSci
- Benefits of publishing null results
- Less wasted science effort and money
How James got into crypto
- Exposed to Bitcoin in college
- Offers financial freedom to bet on self
How Orange DAO works
- $50M fund for crypto projects
- Y Combinator alum support efforts
James’ advice for founders
- Bias toward action
- Be willing to be wrong
Where James sees opportunity in DeSci
- Free flowing access to information
- Get to truth more quickly
What’s wrong with academic science now
- Research for prestige, not passion
- Value determined by citation numbers
How the Alzheimer’s fraud happened
- Conflict of interest at NIH
- No reverse accountability system
What inspires James to invest in DeSci
- Push boundaries of scientific research
- Help scientists build real products
James’ take on the first use case for DeSci
- Data warehousing (null results)
- New forms of publication open to all
James’ definition of success
- Time, space and resources
- Ability to do what you love
Connect with James Sinka
Orange DAO https://www.orangedao.xyz/
Orange DAO on Discord https://discord.com/invite/DVncb7UxGB
Orange DAO on Snapshot https://snapshot.org/#/orangedaoxyz.eth
Orange DAO on Etherscan https://etherscan.io/token/0x1bBD79f1Ecb3f2cCC586A5E3A26eE1d1D2E1991f
Orange DAO on OpenSea https://opensea.io/collection/alumni-gems
Orange DAO on Twitter https://twitter.com/OrangeDAOxyz
James on Twitter https://twitter.com/jamessinka
Resources
Through the Wormhole https://www.imdb.com/title/tt1513168/
Y Combinator https://www.ycombinator.com/
NEAR Protocol https://near.org/
Algorand https://www.algorand.com/
Blockchain Capital https://blockchain.capital/
The Memo by Howard Marks https://link.chtbl.com/thememobyhowardmarks
Multicoin Capital https://multicoin.capital/
Solana https://solana.com/
Exploring Decentralized Science with Balaji Srinivasan https://www.youtube.com/watch?v=xrcRI_hYDtQ
Naval https://nav.al/
Brian Armstrong https://twitter.com/brian_armstrong
Epsilon3 https://www.epsilon3.io/
Benchling https://www.benchling.com/
Amplitude https://amplitude.com/
Sci-Hub https://sci-hub.se/
Patrick Joyce on the Boost VC Podcast https://www.boost.vc/bvc/2022/08/04/desci-ep-2-addressing-the-misalignment-of-incentives-in-science
DeSci Labs https://desci.com/
Connect with Boost VC
Boost VC Website https://www.boost.vc/
Boost VC on Facebook https://www.facebook.com/boostvc/
Boost VC on Twitter https://twitter.com/BoostVC
Boost VC on Instagram https://www.instagram.com/boost_vc/
Bio of The Boost VC Podcast
The Boost VC Podcast, hosted by Adam Draper, Founder and Managing Director of Boost VC, takes listeners on a captivating journey into the realm of emerging technology. With each episode, Adam interviews founders and investors to explore a wide range of subjects, including startup strategies, venture capital, and revolutionary technologies that are shaping the future.
From the captivating world of Bitcoin to the immersive experiences of virtual reality, and from the limitless possibilities of artificial intelligence to the groundbreaking advancements in exoskeletons, drones, and space exploration, The Boost VC Podcast covers it all. By bringing together industry experts and visionaries, the podcast offers listeners unparalleled insights and a deeper understanding of these cutting-edge technologies.
Through engaging conversations, Adam and his guests share their experiences, challenges, and success stories, providing valuable lessons and inspiration for aspiring entrepreneurs and investors. The podcast serves as a platform for industry leaders to share their expertise and shed light on the latest trends and developments that are revolutionizing the tech landscape.
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